Stevens-Johnson syndrome is a multisystemic inflammatory disorder associated with wide spread erythematous eruption that can result in deaths. Sulfonamides are one of the most common agent that produces drug eruptions including Stevens- Johnson Syndrome, However, we had also experienced two cases of Stevens-Johnson syndrome associated with ampicillin and aspirine, and penicilline. Moreover, these drugs caused drug induced hepatitis as well as Stevens-Johnson syndrome in these patients. This was unusual and had not been well documented. We treated them with large doses of steroid, and their mucocutanceous lesions and liver function test were improved.