Since the advent of effective antituberculous chemotherapy, the frequency and severity of intestinal tuberculosis have markedly decreased in the world. However, intestinal tuberculosis continues to be reported with impressive frequency in Korea. But the tuberculous involvement of the stomach and duodenurn is extremely rare event. Recently, we experienced a case of tuberculosis of stomach and duodenum with extensive intestinal involvement. Patient is a 27-year old female and the diagnostic confirmation was attained by histologic findings of endoscopic biopsy specimen. Administration of antituberculous agents resulted in good response. So, we report this case with review of literatures.