Cancer of the pancreas, a malignancy difficult to recognize or treat, has gradually increased. However, little attention has been given to learning about epidemiological background of this particular disease. Fourty one cases with pancreatic malignancy diagnosed by histopathology following the abdominal surgery frorn 1968 to 1986 in this hospital were reviewed retrospectively by us, and the results were as follows: 1) Most prominent group of age was in sixth decade with mean age incidence of 53 year old. Male to female ratio appeared as 3.6: l. 2) Approximately half number of the patients visited to this hospital within three months after the onset of the illness. Most common symptom was abdominal pain in this observation. Either indigestion with anorexia, jaundice or anemia was relatively common symptoms. Twenty one percent in this series was associated with diabetes mellitus. 3) The routine laboratory tests disclosed that low hemoglobin level and increased leukocyte in the peripheral blood, elevated both SGOT and SGPT, raised total bilirubin, or alkaline phosphatase ranging twenty seven to fifty four percent in these patients. 4) The early initial diagnostic procedure of this disease was thought about upper abdominal ultrasonography. The additional studies such as ERCP, Abdominal CT and/or PTC were very helpful. 5) In most cases, the lesion was located in the head of pancreas. The metastasis to regional and 1iver were most frequently found. All of the patients except a case with islet cell carcinoma and a case with mucinous cell carcinoma were as adenocarcinoma. 6) The only seven percent in this observation was performed the radical operation.