We reported the clinical results which were obtained from 328 cases of E.R.C.P. that were performed at the Depatment of Internal Medicine, KANGNAM SCARED HEART Hospital, from May 1980 to July 1986. The results were as follows: 1) The distribution of age was from 11 year to 77 year old. Most of the case were in the 6th decades (52%) and there was no difference in the male to female ratio. 2) The most common complaint of patient was abdominal pain (79%). 3) Success rate for visualization of biliary and/or pancreatic duct was 85.4%. The major cause of failure were unsuccessful cannulation due to papilitis with stenosis. 4) The most frequent shape of Ampulla of Vater was the hemisphelical, followed by papillary and flat type in order. 5) The incidence of biliary and pancreatic cancer was 14.6% and the most frequent site was common bile duct. 6) The most frequent diagnosis of E.R.C.P. was bile stone (57.8%) and its frequent location was C.B.D. followed by cancer, pancreatitis, parasite, and choledochal cyst in order.