Carcinoma of the duodenum is an exceedingly rare disease. The autopsy incidence of duodenal carcinoma is between 0.019 and 0.5%. The malignant tumors spreading to the small hovel are also rare, as evidenced by a frequency rate of 1.14%. The most common tumors spreading to the small bowel are melanomas, adenocarcinoma of the breast, and carcinoma of the lung. Tumors with small bowel spread include those originating in the cervix, ovary, kidney, stomach, and colon. Recently we have experienced a case of colon carcinoma invading duodenum directly and then reported with review of literature.