Scintigraphic studies were performed in 15 normal subjecte, and 33 patients suffering from chronic parenchymal liver disease(liver cirrhosis 7, chronic hepatitis 5, hepatocellular carcinoma 1), and extrahepatic biliary obstruction(CBD stone 8, postoperative CBD stricture 4, pancreatic head ca 4, CBD ca 3, ampullary ca 1) using 99mc-DISIDA. Extraction and excretory functions of hepatocytes were evaluated with respect to liver-to-cardiac blood pool ratio(LCBPR) and washout index(WI). And relationships between these indexs and SGOT, total bilirubin levels were evaluated also. LCBPR was reduced in both patients groups(p< VVI was reduced only in those with extrahepatic biliary obstruction. LCBPR and WI were inversely correlated with total bilirubin levels(r=-0.49,-0 33, respectively).