Simple nonspecific ulcer of the colon is an uncommon lesion but one which surgeons must not overlooked. The etiology is unknown, and the diagnosis has very rarely been made preoperatively. The clinical features are variable depending on the site of the lesion, acuteness or chronicity, and on the presenting complication. The most frequent complication is perforation in the cecal ulcer, and stenosis in the sigmoid colon ulcer. About 50 of all nonspecific ulcers of the colon have occurred in the caecum, and the sigmoid colon has been next commonest site. Case studies of two patients have been presented. Surgical therapy is required for the patient presenting with a complication of simple ulcer, and the choice of surgery is resection of the lesion. Recently, fiberoptic colonoscopy is useful in making a diagnosis of nonspecific ulcer of the colon,