The present study was done to evaluate the effect of ginseng, milk, tea a!id coffee on the production of gastric ulcer in rats. The ginseng, n:ilk, tea and coffee were adminisiered to Shay rat. 3Ve observed the gastric ulceration and determined the gastric acidity, total protcin, muc- oprotein and pepsin concentration of gastric juice "4 hours after administration. The following results were obtained. I. The uler indicies were lov;er in ginseng group and higher in other groups than that of control group. 2. The acidity of gastric juice was increased .-in ginseng group and decreased in coffee yroup. The total and mucoprotein values of gastric juice in ginseng and milk group were significantly increased. The tea and milk group revealed strong stimulating effect on the pepsin secretion.