Gastrodudenal perforation, complicated to the ulcer, cancer and trauma in these organs, is important surgical problems that require emergency operation. In Korea, it was the most frequent causes of panperitonitis and many patients became grave before admission due to easiness of acquirement analgesics at drug stores. So, a clinical and literatural review was made on 157 cases of gastroduodenal perforations which was confirmed by exploratory laparotomy at Dept of Surgery, Han Yang University Hospital from May, 1972 to July, 1977. The results were as follows: 1. The gastroduodenal perforations was occupied RG. 1; of panperitonitis, as 157 cases ger 435 cases. 2. The organic distribution svas manifested as 44 cases t 40. 8%) in stomach, and 93 ca.',es (59. 2%) in duodenum. 3. The Sexual incidence was apeared as 87. 5,o at male (5b cases), and 12. 5Po at female (8 cases) in gastric performations: and 92. 5io at male (SG cases), and 7. 5% at female (7 cases) in duodenal perforations. 4. Gastroduodenal perforations were most frequcntly occurred between April to June, (47. 8i,, 75 cases). 5. Most patients had l to 3 veas of past history but, in 40 cases, there were no past history of ulcer. Fi. At admission, the most prominent physical signs were abdominal regidity (95. 5%, 150 cases) and abdominal tenderness (100%, 157 cases). 7. Pneumoperitoneum were seen at 109 cases (69. 4%) at erect view of simple abdomen or chest P-A. 8. The time from perforation to operation was commonly required 12 hours in stomch perfo- rations and 6 hours in duodenal perforations. 9. The perforation sites were most frequetly fouod at anterior wall of pylorus in stomach and anterior wa]1 of the 1st portion of the duodenum. 10. The procedures of operation were as follows: Subtotal gastrectomy; 3 cases(1. 9%), Vago- tomy and pvloroplasty; 13 cases (8. 3%), Simple closure; 49 cases g.1%), Vagotomy and antrec-tomy; 8 cases (5. 1%) 11. The postoperative complications were developed in 36 cases (23%) and mortality rate,vas 3. 2% (5 cases).