Intrahepatic stone is a disease characterized by recurrent bi]iary colic and higher incidence in Asians than in Caucassians. There are various diagnostic methods for intrahepatic stone, but none are entirely satisfactory except surgical exploration. Since liver scan was introduced by Stirrett, +t aL in 1953, it has been used in the diagnosis of liver diseases such as space occupying lesions, cirrhosis of liver and others. The present study was done to assess the diagnostic value of liver scan in intrahepatic stone. Liver scan was performed on 15 of 28 cases of intrahepatic stone confirmed by operation at Severance Ho- spital, Yonsei University College of Medicine, from January 1969 to June 1971, and ivas compared with those in 17 among 94 cases of other biliary stone. The results were as fo]lows: 1, The incidence of intrahepatic stone in hepatobiliary stone was 22. 9%, the ratio of male to female- was 1: l. 3 and the range of age was 23 to 73 with the mean age of 45. 2, In liver function tests, there were significant increases in the values of total bilirubin, total cholesterol and alkaline phosphatase in both intrahepatic stone and common bile duct stone, while serum albin was low (2. 9+-0. 5gmgy) in intrahepatic stone only. 3. In )iver scan, the characteristic findings of intrahepatic stone were cold areas, mottling and dec- reased uptake, whereas in other biliary stone, the findings were almost normal. The size of cold and . Mottling areas varied from a few mm to a cm, and their location coincided with the site of stones at operation.