Multiple Cutaneous neurofibromas are the most common skin manifestation of Von Recklinghausen neurofibromatosis (NF-1). The CO2 laser is presented as a useful tool for the removal of large numbers of small-or medium-sized cutaneous neurofibromas. Its advantages include high patient satisfaction with the rapid removal of hundreds of neurofibromas, with minimal morbidity and an enhanced appearance. We report a case of multiple cutaneous neurofibromas treated by CO2 laser in a 40 year-old man whom we eliminated 288 cutaneous neurofibromas out of 788 in total. After 3 months of follow up, the lesions were healed with slight erythemas and minimal scars. (Korean J Dermatol 2001;39 (7): 831-833)