Cheilitis granulomatosa, which is a rare inflammatory disorder of unknown origin, was described by Miescher in 1945. A 31-year-old man presented with swelling of both lips without any subjective symptom that had been present for 1 year. The patient had the repeated episodes of upper lip which would resolve in days to weeks that had ended up involving lower lip and eventually persistent. Histopathological study revealed a noncaseating granulomatous inflammation with perivascular lymphocytic infiltration. The patient was treated with systemic steroids and received cheiloplasty. We describe a case of cheilitis granulomatosa improved with systemic steroids and the cheiloplasty. (Korean J Dermatol 2001;39(6): 695~697)