There are many methods to treat condyloma acuminata (CA) such as physical destruction or immunotherapy, but they are not always satisfactory, especially when the lesions occur in young children or infants. Two patients, who showed CA on their anal region, were treated by combination therapy of ED and applying TCA, and were evaluated on the efficacy of the therapeutic method. Clinically and pathologically proven CA was treated with a simple combination method. First, the wart lesions were carefully electrodessicated and swept away, After that, 30% trichloroacetic acid was applied to eroded area. Clinical examination was performed periodically after treatment. Elimination of the CA was successful by one procedure. Complication was not found after treatment.There was no recurrence 1 year later at least. The combination therapy of ED and applying TCA seems to be a very simple, convenient and effective method. (Ann Dermatol 13(1) 48~51, 2001).