Xanthoma disseminatum is a rare disorder that is a distinct subset of cutaneous nonhistiocytosis X. We report a case of xanthoma disseminatum in a 52-year-old woman. She had yellow-brownish variable sized papules or confluent plaques with a well-defined border on her periorbital, perioral, axilla, oral mucosa, neck, scalp, and upper chest areas. There were mixed infiltrations of foamy histiocytes, inflammatory cells, and Touton giant cells in the biopsy specimen. She had been treated with oral fenofibrate but showed no definite effect. (Korean J Dermatol 2000;38(10)：1401~1403)