Drug eruptions are common, occurring in 2% to 3% of hospitalized patients. The majority of reactions are mild, accompanied by pruritus, resolving promptly after the offending drug is discontinued. An eruption caused by itraconazole is very rare and there have been no previous reports in Korea. A 60-year-old man was seen with multiple erythematous papules and patches that appeared after oral administration of itraconazole and gradually the skin lesions changed to purpura. Given the widespread use of itraconazole for onychomycosis, a purpuric drug eruption should be considered a rare complication of therapy.