Background: Defective adhesion and migration of melanocyte may be involved in pathogenesis of vitiligo. Tenascin, a glycoprotein of the extracellular matrix, has a role in cell adhesion and migration. It has been reported that abundant expression of tenascin in vitiligo lesion may inhibit melanocyte adhesion and migration. Objective: To investigate the tenascin expression in vitiligo skin lesions and to compare with clinical findings. Methods: We studied 9 patients with vitiligo. The expressions of tenascin were studied by immunahistochemieal techniques. (continue...) (Korean J Dermatol 1999;37(4): 495-499)