반응성 천공성 교원증(Reactive Perforating Collagenosis, RPC)은 표재성 외상에 의해 변형된 교원질이 표피를 통해 제거되는 비교적 드문 질환으로 선천성 형과 후천성 형의 두 형태로 나누어지며, 이중 후천성 형은 성인에서 발병하고 가족력이 없으며 흔히 당뇨병, 신장질환, 갑상선 질환, 림프종 및 AIDS 등과 동반된다. 저자들은 후천성 반응성 천공성 교원증 3예를 경험하고 문헌 고찰과 함께 보고하고자 하며 아울러 전자현미경 검사를 시행하여 미세구조적인 변화도 함께 관찰하였다.

Reactive perforating collagenosis(RPC) is a rare perforating disorder characterized by transepithelial elimination of altered collagen. Two types of RPC occur:inherited and acquired. The acquired type arises during adult life without a familial tendency. It is accompanied by scratching and usually is associated with diabetes mellitus, chronic renal failure, lymphoma and AIDS. We report three cases of the acquired form of RPC. Pruritus was the common factor among them. In two patients, chronic renal failure and hyperthyroidism were associated with RPC. Histopathological and ultrastructural findings showed transepithelial elimination of collagen. Control of itching was helpful for clearing the lesions.(Kor J Dermatol 1997;35(1):204∼208)