Infectious endocarditis is associated with five cutaneous findings.'subungal hemorrhages, Roth spots, Oslers nodes, the Janeway lesion and petechiae, which are infrequently reported in the current antibiotic era. The Janeway lesion, first described by Edward Janeway in 1899, is an erythematous or hemorrhagic, non-t.ender macule or nodule several centimeters in diameter occurring on the palms or soles. We report a case of a Janeway lesion in a 30-year-old woman, who had pruritic nontender macules with fever of unkown origin. Our case demonstrates the importance of careful skin examinat,ion in systemic diseases such as infectious endocarditis. The findings of the Janeway lesion in this woman were important in securing t.he early clinical diagnosis of infectious endocarditis (Kor J Dermatol 1996;34(6): 9~93-997)