Background : Despite concern about treatment of sporotrichosis, little is known about the sensitivity of S. schenckii against antifungal agents. Objective : The purpose of the study was to investigate minimal irihibitory concentration(MIC) of antifungal agents against S.chenckii. Methods : The tested strains were seven in number. The tested antifngal agents were ketoconazole, itraconazole, amphotericin B, and potassium iodide. A various concentration of drugs were mixed into fluid media containing 50% ethanol, dimethyl sulfoxide, and distilled water. The inoculum consisted of 3mm block containing hyphae and spores. Results : MIC ranges of ket.oconazole, itraconazole, amphotericin B, and potassium iodide were 0.39- 25pg/ml, 0.78-25pg/ml, 0.78-25pg/ml, and 75-550pg/ml, respectively. Conclusion : We find that ketoconazole is the most active drug against S. schenckii. (Kor J Dermatol 1993;31(6):884-889)