We cairried out this study to find the possibility of itch control with acupuncture under the hypothesis that antipruritic effect also exists if the itch sensation is closely allied to pain. We evaluated the effect of acupuncture on histarnine induced itch, flare and wheal in 20 healthy male volunteers aged 24 32 years old and compared it with the effect of pseudoacupuncture on them and that of no intervention on them. The results were as follows: 1. Mans of itch intensity and duration were decreased in A(session with acupuncture) and P(session with Pseudoacupuncture), compared to those of N(session with no intervention), and A was more effective in decreasing the itch intensity and its duration than P. 2. Means of maximal sizes of flare and wheal were smaller in A and P, but there was no remarkable difference between A and P.