The specific cutaneous lesions of acute myeloblastic leukemia was described, in which the skin lesions were the initial sign of the leukernia and the performance of the bone marrow aspiration led to correct diagnosis. A 55 year old man had admitted to our hospital with complaints of multiple nodules and tumors on the skin. Four month prior to admission, he had noticed small papules on his back. These lesions become nodular, increased in size and number. And then spread to anterior chest, extremities and face. Skin biopsy specimen showed diffuse dermal and subcutaneous infiltration of abnormal cells that appeared to be leukemic cell in nature. Bone marrow biopsy specimen showed changes of acute myeloblastic leukemia. Treatment was initiated with combined chemotherapy (cytosine arabinoside and adriamycin) and the eruption began to fade away.