A case of infantile acropustulosis(I.A.). ariginally reported by Kahn, was seen at the Department of Dermatology, Catholic Medical College in September 1979. An 11 month old male patient had been suffering from 1~2mm sized severe pruritic pustules on both hands and feet from 3 months of age. The lesions had the course of exacerbations and remissions from the onset and aggravated since last summer. The eruptions did not respond to topical and oral steroids and antiboitics. There was no family history of atopy, psoriasis and scabies. Histopathological findings revealed large, well circumscribed, intraepidermal pustules which were filled with neutrophilic polymorphonuclear leukocytes. The scraping tests for S. scabiei and dermatophytic fungi were negative. Bacterial culture from the pustular lesions was negative. Treatment was done with 4,4-diaminodiphenylsulfone(Dapsone), 2mg/kg/day in devided doses. Dramatic effect was noted within 2 days after treatment.