This relatively uncommon malignant melanoma (incidence less than 5/100, 000 population) is attested to by the fact that despite accounting for only 3% of all cutaneous malignant neoplasms and causes 67% of the deaths attributabIe to skin cancer. Sunlight pIays a major role in. the development of melanoma. Several factors influence the clinical course of malignant melanoma, such as sex, site, type of ma1ignant melanoma, degree of cellular anaplasia, inflammatory reaction and thickness of the lesion. Two caees of malignant melanoma were presented. The one was 55 year old male who had been suffered from large pea sued blackish ulcerative lesion on the lft sole aince 3 years before. The other one was 66 year old female wha had been suffered frorn walnut sized ulcerative lesion on the right inner wrist joint with regional lymph adenopathy since 2 yea,ra before. The patient was treated with wide surgical excision, regionaI lymphnode dissection and subcutaneous injection with Tubercin-3. The first male patient was treated completely but second female patient shows recurrence of the lesion on the right forearm and upper arm within 40 days.