Traditionally, a positive bone scan shows single or multiple areas of increased uptake in them metastatic skeletal disease. The occurence of "cold" lytic-like or photon-deficient lesions in bone imaging is probably uncommon. Photon-deficient focus or cold lesion of the sternum was demonstrated on Tc-99m-MDP bone imaging in 2 individuals with acute myloid leukemia and primary hepatoma, respectively.