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3.148.105.152
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SCIE SCOPUS
인슐린비의존형 당뇨병 환자에서 미세 및 대혈관 합병증에 따른 안지오텐신 1 전환 효소 유전자의 다형성
Angiotensin 1 Converting Enzyme ( ACE ) Gene Polymorphism According to Micro - and Mocro - angiopathy in non - insulin Dependent Diabetes Mellitus
남문석(Moon Suk Nam), 이현철(Hyun Chul Lee), 이지현(Ji Hyun Lee), 차봉수(Bong Soo Cha), 남수연(Su Youn Nam), 송영득(Young Duk Song), 임승길(Sung Kil Lim), 김경래(Kyung Rae Kim), 허갑범(Kap Bum Huh)
UCI I410-ECN-0102-2009-510-005469711
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Background: Chronic micro- and macro-angio- pathy in diabetes are clinically significant complications that affect both quality and length of life in diabetic patients. Angiotensin 1 converting enzyme (ACE) is of key importance in regulating systemic and renal circulation by converting angiotensin-1 into -2 and inactivating bradykinin, Recent reports suggest that the ACE gene polymorphism is associated with susceptibility to micro- and macro-angiopathy in diabetes. But the results are diffetent according to the type of diabetes and complication. Methods: We investigated the alleles of the ACE gene and measured the ACE activity in the 169 cases of non-insulin dependent diabetic patients and in the 95 cases of controls matched with age and BMI. Results: The measured ACE activity was well correlated with the count of D allele. We found no differences of ACE alleles between in diabetes and control. No association was found between ACE gene polymorphism and diabetic microangiopathy(retinopathy or nephropathy). But DD genotypes (homozy- gotes for the deletion polymorphism) and D allele were found more frequently in diabetic patients with coronary artery obstructive diseases than in patients without coronary artery obstructive diseases in coronary angiography. Conclusion: These data indicate that ACE gene polymorphism in non-insulin dependent diabetes is associated with coronary artery obstructive diseases, but not with chronic microangiopathy.

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