18.97.9.169
18.97.9.169
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SCIE SCOPUS
인슐린비의존형 당뇨병 환자에서의 β3 - adrenergic 수용체 유전자 다형성
The β3 - adrenergic Receptor Gene Polymorphism in Non - Insulin Dependent Diabetes Mellitus
이지현(Ji Hyun Lee), 이해일(Hai Ri Li), 이상원(Sang Won Lee), 남수연(Su Youn Nam), 원영준(Young Jun Won), 차봉수(Bong Soo Cha), 남문석(Moon Suk Nam), 송영득(Young Duk Song), 이은직(Eun Jig Lee), 임승길(Sung Kil Lim), 김경래(Kyung Rae Kim), 이현철(Hyun Chul Lee), 허갑범(Kap Bum Huh)
UCI I410-ECN-0102-2009-510-005470165
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Background: The B3-adrenergic receptor, located mainly in adipose tissue, is known to be involved in the regulation of lipolysis and thermogenesis. Recently studies have shown that the B3-adrenergic receptor gene polymorphism is associated with Non-Insulin Dependent Diabetes Mellitus(NIDDM) and insulin resistance. We investigated the relationship between the B3-adrenergic receptor gene polymorphism and the cli!ical and biochemical features of NIDDM patients. Methods: Anthropometeric and biochemi al characteristics were determined for 134 NIDDM subjects and 30 nondiabetic controls. All subjects were genotyped for the 0-adrenergic receptor gene mutation using restriction fragment length polymorphism assay. Results: The allelic frequency of the mutated allele was similar in NIDDM subjects and nondiabetic controls(11%, 12% respectively). There was no difference in the Arg64 allelic frequency of the B3-adrenergic receptor gene according to the onset age of diabetes. In diabetic group, the clinical and biochemical characteristics were not statistically different between the B3-adrenergic receptor gene mutation and nonmutation group. In control group, also no clinical differences were found between mutation and non- mutation group. When comparing frequency of obesity according to the B3-adrenergic receptor gene mutation in diabetic patients, we did not find the difference between the two groups. Conclusion: These results suggest that the b3-adrenergic receptor gene is not a major determinant for the development of obesity and NIDDM in Korea.

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