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Background: Diabetes produce degenerative changes in vascular beds. The vessel lesions in skin and muscles are more frequently involved than in kidney and retina. For evaluation of Diabetic microangiopathy, Doppler Flow Velocity Waveform Analysis (FVWFA) was performed iin peripheral arteries(dorsalis pedis artery and radial artery). Method: We divided 88 persons into four groups; group I, 28 diabetic patients below 50 years-old age; group II, 32 diabetic patients above 51 years-old age; group III, 14 healthy controls below 50 years-old age, group IV, 14 healthy controls below 50 years-old age. Four waveform dimensions for different degrees of peripheral obstructive arteriolar disease were determined on velocity tracing. We used a single discriminant equation. Results: 1) Discriminating score(D.S.) showed significant differences between groups of diabetic patients(group I and II) and control subjects(group III and IV). D.S. of NIDDM patients were -4.5+4.1 in dorsalis pedis artery and 0.1+3.7 in radial artery. D.S. of control group were 0.5+5.6 in dorsalis pedis artery and 3.2 +3.5 in radial artery. 2) Discriminating score, derived from FVWFA on dorsalis pedis artery and radial artery, showed significant differences between group I and III. D.S. of group I were -6.1 + 3.2 in dorsalis pedis artery and -0.2+1.9 in radial artery and group III were 2.8+5.9 in dorsalis pedis artery and 6.2+3.3 in radial artery. Conclusion: We believed that doppler flow velocity waveform could be useful, relatively simple, and sensitive method in early and correct clinical diagnosis and follow-up of diabetic microangiopathy.