Objective: Implantation is a complex process between developing embryo and maternal endometrium, especially decidua. Decidua is a specialized endometrium during pregnancy and decidua basalis is the real implantation site infiltrated directly by trophoblast cells. The decidua parietalis lines the uterine cavity away from the implantation site, not real implantation site. TGF- β1 and TGF-β2 have known as multipotential cytokines and expression of TGF- p and TGF-/3. increased in decidua during pregnancy than secretory phase of endometrium. However, there is little known about their expression in decidua parietalis, compared with decidua basalis. The purpose of this study was to compare the expression of TGF-β1 and TGF-β2 in the decidua basalis and decidua parietalis during early pregnancy. Methods: The early pregnant 26 samples were obtained at hysterectomy, which underwent surgery for cervical carcinoma, ovarian cancer, etc. Immunohistochemical staining of TGF- β1 and TGF-β2 was performed and staining intensity was semiquantified by using HSCORE. Results: TGF-β1 was slight]y expressed in the decidua basalis and decidua parietalis and there were no differences among them. But the expressions of TGF-β2 of stroma and glandular cells were higher in the decidua basalis than parietalis (p < 0.005). And the expressions of TGF-β2 were stronger than that of TGF-β1 in the both decidua of ear]y pregnancy (p < 0.005). Conclusion: In decidua basalis, especially stromal cells, the expression of TGF-β2 was increased than in the decidua parietalis. This suggests that TGF-β2 may play an important role in decidua basalis that is directly invasion site by embryo and can be regulated by embryonic derived local factor. TGF- 2, compared with TGF- β1, was increased in both implantation site and suggest it may regulate implantation process during early pregnancy.