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폐경후 여성에서 골대사 표지물질을 이용한 알렌드로네이트의 골다공증 치료제로서의 유용성에 관한 연구
Clinical Usefulness of Alendronate for Osteoporosis in Postmenopausal women
여민구(Min Goo Yeo),송승훈(Seung Hoon Song),이재관(Jae Gwan Lee),허준용(Joon Yong Hur),서호석(Ho Suk Seo),박용균(Yong Gyun Park),조수용(Soo Yong Jo)
UCI I410-ECN-0102-2009-510-005329230

Objective : To evaluate the usefulness of alendronate for prevention and treatment of postmenopausal osteoporosis this study was taken. Methods : This prospective randomized clinical trial examined the effects of oral alendronate and HRT(conjugated estrogen plus medroxyprogesterone acetate), in combination and seperately, on BMD, biochemical markers of bone turnover in 79 women with low bone mass. Treatment included alendronate(10mg daily) plus HRT(group I, n=38), or HRT(group II, n=41) for 6 months. Bone density measurements were performed at months 0 and 6 at the lumbar spine. Biochemical markers of bone turnover were also measured every three months. Results : Serum Osteocalcin decreased by 19.2% in group I and by 10.0% in group II at 3 months(p<0.05), and by 30.9% in group I and by 19.8% in group II at 6 months(p<0.05). Urinary deoxypyridinoline showed decrease of 19.75%(I) vs. 10.4%(II) at 3 months, 30.1%(I) vs. 20.7%(II) at 6 months, the difference was significant. Percent change of BMD measurements from baseline at 6 months in group I was 6.2% and in group II 0.6% on the lumbar spine(p<0.05). Conclusion : The treatment with alendronate is useful to postmenopausal women with osteoporosis by decreasing bone turnover markers, and by increasing the BMD.

[자료제공 : 네이버학술정보]
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