본 예에서는 임신 18주에 완전 포상기태와 공존한 생존 태아로 된 쌍생아 임신에서 임신중에 중증의 임신성 고혈압 증세를 보였고, 임신중절 후 추적 관찰 중 지속성 임신성 융모상피종양이 발병하여 단일 약제 항암치료를(methotrexate with folinic acid) 시행한 경우로 그 진단 및 치료에 대한 간단한 문헌 고찰과 함께 보고하는 바이다.

Twin pregnancy with a complete hydatidiform mole and a coexisting fetus is a rare occurrence with a reported incidence of 1:10,000 to 1:100,000 pregnancies. This condition has an aggressive postevacuation behavior; it is, therefore, important to differentiate these cases from partial hydatidiform mole that rarely require treatment for late sequelae. Usually this case is diagnosed prenatally by ultrasonography. Following evacuation, careful hCG monitoring is mandatory since it is the most reliable and sensitive method for the early detection of gestational trophoblastic tumor. In carefully selected patients in whom the risk of developing gestational trophoblastic tumor is significant or when the availability of hCG testing is suboptimal, chemoprophylaxis has been shown to decrease the risk of gestational trophoblastic tumor. We report here a case of patient, developed persistent gestational trophoblastic tumor associated with hydatidiform mole with coexisting live fetus, treated by single agent systemic chemotherapy.