1996년 5월 1일부터 1997년 4월 30일까지 본원 산부인과에서 양수천자법을 시행받은 74명의 임산부에 대하여 양수천자의 적응증, 시기, 양수의 색, 세포유전학적검사 등을 관찰하여 다음과 같은 결과를 얻었다. 1. 과거에는 양수천자의 적응증이 주로 dvanced maternal age 이었으나, 최근 본원의 조사에서와 같이 주적응증이 abnormal maternal serum marker로 바뀌는 것으로 생각한다. 2. Early amniocentesis를 2예에서 시행하였다. 3. 55예에서 바늘 1회 삽입으로 양수채취에 성공 하였고, 3회 이상 바늘 삽입 예는 6예가 있었다. 4. 양수의 색은 55예에서 clear하였고, 9예에서 bloody 하였으며, 2예에서 brownish하였다. 5. 1예에서 Kleinfelter증후군의 염색체 이상을 발 견하였다.

Amniocentesis was first performed for genetic studies in the 1950s. Serr and colleagues, and Fuchs and Riis were the first to report the use of amniocentesis for antenatal sex determination. From the 1970s, genetic amniocentesis became one of the most useful techniques of the prenatal detection of genetic disorders. Because the application of population-based maternal serum screening to prenatal diagnosis is now widespread, we can estimate the trend change of amniocentesis indications. So this study was carried out from May 1996 to April 1997 on 74 pregnant women who underwent amniocentesis in an university hospital in order to analyse the indications, age distribution, gestational age at the time of amniocentesis, frequency of needle insertions, color of amniotic fluid, outcome of pregnancy, and result of chromosome analysis. The results obtained are summarized as followings. 1. The most common indication for amniocentesis was abnormal maternal serum marker. 2. Two earl amniocenteses were performed. 3. 55 cases were single needle insertion and 6 cases were 3 or more needle insertions. 4. 11 discolored fluids[9 bloody, 2 brownish] were obtained during genetic amniocentesis of 74 patients. 5. Chromosomal abnormality was detected in one case of the 74 total cases.