ASCUS의 세포학적 진단후 치료방침으로 질확대경 검사를 할 것인지 혹은 관찰을 할 것인지의 객관적인 선별검사로서 HPV 감염검사는 의의가 있다. 이상의 결과로 보아 세포진검사에서 ASCUS로 나온 여성은 질확대경과 생검에 의뢰하는 선별검사로서 hybrid capture에 의한 HPV 검사를 함으로써 의의있는 정확성과 예측도를 얻을 수 있었다. 세포진검사에서 ASCUS 이상의 소견을 보이고 HPV에 감염이 된 환자는 반드시 질확대경검사를 통하여 조직검사까지 시행하는 적극적인 방법이, 자궁경부암의 조기발견 및 치료에 유익할 것으로 생각된다.

Objective: Our purpose was to determine the clinical value of human papilloma virus deoxyribonucleic acid testing with the hybrid capture test, specifically to examine whether human papillomavirus testing could identify which women with Papanicolaou smears read as atypical squamous cells of undetermined significance were most likely to have histologically confirmed cervical intraepithelial neoplasia. Study Design: Hybrid capture testing for high-risk human paillomavirus types(type 31, 33, 35, 45, 51, 52, 56), repeat Papanicolaou smears and colposcopically directed biopsies were performed concurrently on 55 women refered to chosun university hospital with a previous Papanicolaou smear read as atypical squamous cells of undetermined significance. Results: Human papillomavirus eoxyribonucleic acid positivity was associated with a six fold increased likelihood of histologic confirmation of cervical intraepithelial neoplasia. The sensitivity of hybrid capture for any cervical intraepithelial neoplasia was 92% (12/13) and specificity was 86%(36/42), whereas the corresponding values for the repeat Papanicilaou smear was 85%(11/13) and 38%(16/42), respectively. Conclusions: Testing for human papillomavirus deoxyribonucleic acid with hybrid capture appears to offer an effective means by which patients whose cervical Papanicolaou smears have been read as atypical squamous cells of undetermined significance could be triaged for colposcopy. In particular, high sensitivity and specificity for cervical intraepithelial neoplasia could be maintained.