중앙대학교 의과대학 산부인과학교실에서는 1994년 1월부터 1995년 7월까지 자궁내막증 환자의 복강액이 정자의 운동성과 운동매개변수에 미치는 영향에 관한 연구를 실시하고 그 결과를 비교 분석하여 다음과 같은 결론을 얻었다. 1. 대조군에 비해서 자궁내막증군에서 전반적으로 운동성의 감소를 보였다. 24시간 경과후 대조군의 71.7%에 비해 자궁내막증 1기에서 59.0%, 2기에서 53.2%, 3기에서 54.7%, 및 4기에서 57.1%로 각각 통계적으로 의의있는 감소를 보였다(p

The exact mechanism of infertility in women endometriosis is unknown, although many reasons have been presented. Infertility associated with endometriosis may be mediated by the detrimental effect of peritoneal fluid(PF) on spermatozoa, oocytes or embryos. The purpose of his this study was to evaluate the effect of PF from patients with endometriosis on sperm motility using computer assisted sperm analysis(CASA). Samples of PF were collected from the Douglas puch of women undergoing pelviscopy for infertility or laparotomy. Samples of follicular fulid(FF) were aspirated from women undergoing treatment in IVF program. The prepared spermatozoa were incubated in PF from pateints without endometriosis(Control group, n=28), in PF from stage 1 endometriosis(EM I group, n=28),in PF from stage 2 endometriosis(EM II group, n=28), in PF from stage 3 endometriosis(EM III group, n=28), in PF stage 4 endometriosis(EM IV group, n=28), and in follicular fluid(FF group, n=28). The sperm motilityn parameters(curvilinear velocity(VCL), amplitude of lateral head displacement(ALH), beat cross frequency(BCF), straightness(STR), and linearity(LIN)) were measured after 1,5, and 24 hours incubation. The sperm motility in EM IV group after 24 hours incubation was 57.1 % which was significantly lower in EM IV group after 5 hours incubation was 43.6% which was significantly lower than that of control group, 53.5%(p