저자들은 서울대학교병원 산부인과에서 체외수정 시술후 발생한 난소 과자극증후군에 동반 된 뇌혈관 혈전색전증 1예를 경험하엿기에 문헌고찰과 함께 보고하는 바이다.

Although there have been many advances in monitoring techniques, severe ovarian hyperstimulation syndrome(OHSS) still occur approximately in 1% of patients treated with ovulation induction agents in assisted reproductive technology(ART) program. the pathogenesis of OHSS is unclear, but the proposed mechanism is the production of vasoactive substances resulting in the increased local capillary permaeability and the fluid shift from the intravascular space into the third space . This fluid shift into the third space may cause ascites, hypovolemia, oliquria, hemoconcentration thromboembolism, and even death. Most cliniciated in thromboembolism in OHSS are the increased blood viscosity due to hemoconcentration, the alteration in coagualtion factors, the venous compression due to enlarged ova-ries and ascites, and the immobilization of patients. We have experienced a case of severe OHSS with a complications of cerebrovasular thromboemboslism in in vitro fetilization(IVF) patient and present it with the review of literatures.