자궁내 감염과 조기 분만과의 상관관계를 규명하기 위하여 조기분만된 산모 태반의 병리조 직학점 염증 소견을 만삭 분만된 산모의 것과 비교하였다. 1992년 1월부터 1993년 12월까지 영동 세브란스 병원산부인과에 입원한 116명의 조기 분만산모를 대상으로 그리고 만삭분만 산모 134명을 대조군으로하여 다음의 결과를 얻었다. 1. 조기파막이 없는 86예의 조기 분만과 121예의 만삭분만한 산모 태반의 분석에서 조직학 적 융모양막염과 조기분만과의 연관성이 관찰되었다. (조기분만 15.12%, 만삭분만 5.82% p=0.02). 2. 조직학적 융모양막염은 조기분만의 경우에도 임신 주수가 빠를수록 더욱 심하였다. 3. 탈락막염은 양군에서 비특이적이다 (조기분만 25.6%, 만삭분만 32.2% p>0.1). 4. 분만 방법과 진통을 고려하였을 경우에도 조직학적 융모양막염과 조기 분만과의 관련성 의 경향을 보여 주었다. (보기분만 26.72%, 만삭분만 11.53%,p=0.05).

Objectives : To compare the placental infalammation between preterm and term deliveries. Methods : Placentas were obtained in 116 preterm and 134 term single live births at the Yonsei University Medical Center between January 1992 and December 1993. Pathlogic examination of placenta was done by two pathologists. Examnied placental sites were fetal membrane , placental disc, decidua, and umbilical cord. Student`s test and Fisher`s exacte test were used for statical comparisons. Results : 1) The prevalence of histologic chorioamnionitis in premature ruptrue of membrane (PROM) group tends to be higher in preterem(46.7%) deliveries(term 15.4% p=0.05). In intact membrane group, the result was satistically significant between preterm(15.12%) and term(5.82%) deliveries(p=0.02) 2) In 207 patients with intact membrane , associations between placental inflammation and preterm deliveries were statistically significant in chorioamnionitis and cord inflammation(preterm 5.8%, term 0%, p0.1) 3) In 43 patients with PROM no significant association was noted between placental inflammation and preterm deliveries. 4) Histologic choriamnionitis was more severe in preterm deliveries. 5) in 97 patients delived vaginally with intact membrane , the prevalence of histologic choriamnionitis tends to be higher in preterm (26.7%) deliveries(term 11.5% p=0.05). Conclusion : There was significant association between histologic choriamnionitis and preterm deliveries, and the degree of choriamnionitis was severe in ealier gestation. After controlling mode of delivery and labor, borderline association presisted between histologic choriamnionitis and preterm deliveries. Futher study will be needed.