p53 유전자와 c-erbB-2 유전자는 정상세포나 대조군에서는 전혀 발현되지 않은 반면 자궁경부암조직에서는 의의있게 발현되었고 p53 유전자는 진행된 병기나 병소의 크기가 클수록 강한 발현정도를 보여 예후인자로서의 가능성을 시사하였으나, c-erbB-2 유전자의 발현은 예후 인자와 관련하여 의의가 없었다.

We investigated the diagnostic usefulness of the demonstration of p53 and c-erbB-2 immunoreactivity in cervical cancers, because immuno-histochemical demonstration of p53 immunoreactivity is inexpensive, easily controlled and can be applied in routine pathology laboratories. p53 and c-erbB-2 immunoreactivity was not identified in any patients in whom there was no morphological evidence of neoplasa. In contrast, in 73% of patients of cervical cancer, p53 immunoreactivity was identified, and in 23% of patients, c-erbB-2 was identified. Overexpression of p53 gene correlates with advanced stage and large sized lision, but c-erbB-2 does not correlate with any prognostic factor.