1984년 1월부터 1993년 12월까지 만 10년동안 원주기독병원 산부인과에서 수술후 악성 배세포종양으로 진단된 19예를 조사분석하여 다음과 같은 결론을 얻었다. 1. 악성 배세포종양의 빈도는 전 난소종양의 27%였고 배세포종양의 13.5%을 차지하였다. 2. 조직학적 분류에 따른 종양분포는 미분화세포종 8예(42.1%)로 가장 많았고 미성숙기형종 6예(31.6%), 혼합배세포종 3예(15.8%) 그리고 내배엽동종양과 태생암이 각각 1예(5.3%)의 순이었다. 3. 환자의 연령은 8세부터 31세까지 분포하였고 평균연령이 17.4세로 10대에서 가장 많았다. 4. 암기의 분포는 I기가 16예(84.2%)로 가장 많았고, III기 1예(5.3%), IV기 2예(10.5%)순이었으며 II기는 없었다. 5. 종양표지물질로써 a-FP은 혼합배세포종에서 의의있게 증가하였으며, b-HCG는 혼합배세포종과 미분화세포종에서, CEA는 미성숙기형종, CA-125는 미성숙기형종에서 각각 의미있게 증가하였다. 6. 수술후 보조적 항암화학요법은 13예에서 시행하였으며 병합화학요법으로 주로 VAC 사용하였으며 7회이상 보조적 화학요법후 이차 추시개복술 시행하였던 6예중 4예(67%)에서 완전관해율을 보였고 2에서 잔류종양이 있었다. 7. 사망한 2예는 내배엽동종양과 미분화배세포종으로 구성된 혼합배세포종이었고 각각의 생존기간은 32개월과 28개월이였다.

This study was planned to evaluate the clinical and histopathological status of the ovarian malignant germ cell tumor, which was made on a series of 19 cases with ovarian malignant germ cell tumor, who were admitted, operated and confirmed with postoperative histopathological study at department of obstetrics and hynecology, Yonsei University Wonju Christian Hospital, during the period of 10 years from 1984 Jan. to 1993 Dec. The result obtained were as follows: 1. The incidence of malignant germ cell tumor among 691 cases of ovarian tumor and 141 cases of germ cell tumor were 2.7%(19/691) and13.5%(19/141). 2. Among malignant germ cell tumors by histopathological classification, dysgerminoma was most frequently reveal in 8 cases(42.1%), immature teratoma in 6 cases(31.6%), mixed germ cell tumor in 3 cases(15.8%), endodermal sinus tumor in 1 case(5.3%), embryonal carcinoma in 1 cases(5.3%). 3. Age distribution revearled between 8 and 31 years old, mean age was 17.4 years old, most frequently revealed in teenager. 4. According to FIGO classification, the patients were classified as; Stage I 84.2%, Stage III 5.3%, Stage IV 10.5%. 5. According to tumor markers, a-FP was increased in mixed germ cell cumor, b-HCG in mixed germ cell tumor and dysterminoma, CEA in immature teratoma, CA-125 in immature teratoma. 6. Six of 19 cases who were treated with multiple agent combination chemotherapy(VAC) underwent second-look procedure, and 2 cases have developed recurrence, 4 cases have completely remission. 7. Two cases have did who have endodermal sinus tumor and mixed germ cell tumor, and interval to death was 32 month and 28 month.