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인간의 체외수정과 투명대제거 햄스터난자의 침투 등에 관한 연구
Correlation of Human In Vitro Fertilization with the Zona-Free Hamster Peneration Assay
김재명(JM Kim),조경숙(KS Cho),서병희(BH Suh),이재현(JH Lee),정길생(KS Chung)
UCI I410-ECN-0102-2009-510-005350837

정액검사 및 체외수정후 난자의 수정, 난할율과 상호 비교분석하여 다음과 같은 결론을 얻었다. 1. 대상환자의 평균정액량은 2.9±1.4 ml 농도는 68.9±38.6±106/ml 운동성은 57.7±4.7% 였다. 2. 난자 채취율은 평균 3.3±1.9개였으며, 2.2±1.9개가 수정되어 87.9%의 수정율 및 90.5%의 난할율을 나타냈다. 3. HPA결과치는 평균39.3±29.0% 로서 난자당0.65±0.74개의 정자가 침투하였다. 4. 15명중 5명에서 원정액보다 낮은 운동성을 나타냈으며 이들의 평균HPA 결과치는26.6±32.0% 로서 전체의 평균 HPA결과치보다 낮았다.

We compared fertility potential measurements by the zona-free hamster egg penetration assay with the in vitro fertilization of human eggs. Spermatozoa from 15 husbands participating in an in vitro fertilization and embryo transfer problem was evaluated for their ability to fertilize zona free hamster egg. The average fertilization percentage was 39.3(range 0 ∼ 95.2%). In two cases, a positive fertility assessment was obtained in the absence of fertilization of the wives`s eggs attributable to egg immaturity. In four cases, a negative fertility assessment was attribute to the decrease of the motility of prozen semen at thawing. These results indicate that hamster penetration assay is highly correlated with the fertilization of human eggs in vitro.

[자료제공 : 네이버학술정보]
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