서울대학교병원 산부인과에서 1988년 7월부터 1990년 4월까지 13명의 불임환자를 대상으로 단순 호르몬대체요법을 이용한 난자공여 프로그램을 15주기 시행한 결과 6명의 환자에서 임신이 성립되었다. 난자공여 프로그램은 난자공여를 필요로 하는 불임환자의 치료에 있어서 효과적이고 실용적인 치료방법이 될 수 있으며, 배아의 착상기전, 임신 초기의 내분비학적 변화 등에 관한 중요한 지식을 제공할 수 있을 것으로 사료된다.

It has been well recognized that both the synchronization of luteinizing hormone(LH) surge between the donor and the recipient for normally cycling women and the complex steroid replacement regimen given on a sequential and incremental basis for women with primary or secondary ovarian failure are two important aspects in oocyte donation. In oocyte donation program at our center, a simplified hormonal regimen applicable both to normally cycling women and to those with ovarian failure which consisted of administering 2 mg estradiol(E2) valerate orally three times daily augmented with 100 mg progesterone(P) in oil intramuscularly daily starting on the day preceding the oocyte retrieval from the donor was utilized. From July 1988 to April 1990, 15 cycles of oocyte donation program in 13 infertile patients were undertaken and 6 patients succeeded in pregnancy with the pregnancy rate of 46.2% per patient and 40.0% per cycle.