1,320∼2,090gm의 가토 60마리에게 태변에 염색된 양수와 태변에 염색 안된 양수 3,5cc를 각각주입한 후 24, 48, 72시간 경과후 도살하여 폐조직에 미치는 영향 및 폐조직 변화를 정상 대조군 1마리와 비교, 관찰하여 다음과 같은 결론을 얻었다. 1. 1,220∼2,090gm의 가토에 태변 염색된 혹은 태변 염색 안된 양수를 주입 후, 토끼폐에서 폐부종, 울혈 및 출혈, 폐포 중격조직에 림파세포 침윤, 폐포내 심한 호중구 침윤 등이 나타났다. 2. 태변 염색 양수군에서는 흡인성 폐렴이 많이 발생하였고, 반면에 태반 비염색 양수군에서는 폐부종, 폐울혈 및 출혈과 간질성 폐렴이 많이 발생하였다. 무기폐는 양군에서 1마리만 발생하였다. 3. 태변 염색 양수군의 흡인성 폐렴 발생율은 3cc의 경우 24, 48, 72시간 경과시 각각 40, 40, 80%로 5cc의 경우는 각각 80, 100, 80%로 나타났다. 태변 비염색 양수군의 흡인성 폐렴 발생율은 3cc의 경우 48시간 경과시 20%로 나타났고, 5cc의 경우 72시간 경과시 80%로 나타났다. 4. 흡인성 폐렴은 양측 폐에서 18마리, 우측 폐에 5마리, 좌측 폐에 3마리가 발생하였다.

The purpose of this study is to investigate the histopathological change in the lungs of rabbit aspirated amniotic fluid with or without meconium staining from pregnant women. After amniotic fluid were injected into the trachea of rabbits, whether meconium stained or meconium nonstained, it was observed the histopathological change in the lungs, comparing 60rabbits with 1 normal control rabbit according to the duration(24hrs,48hrs,72hrs) and the amount(3cc,5cc) of amniotic fluid injected. The results were as follows; 1. After amniotic fluid were injected into the trachea of rabbits, 1220-2090gm, the following phenomena were found;pulmonary edema, pulmonary hemorrhage, pulmonary congestion, lymphocytic infiltration in the interstitial alveolar septa, severe neutrophil infiltration in the alveoli. 2. The incidence of aspiration pneumonia in the meconium stained group was higher than that in the meconium nonstained group. But pulmonary congestion, pulmonary hemorrhage and interstitial pneumonia in the meconium nonstained group occurred higher than the meconium stained group. Atelectasis was observed only one case in both groups. 3. The incidence of aspiration pneumonis in the meconium stained group was in the case of injecting 3cc meconium stained 40%,40%,80% according to the time passed 24hrs,48hrs,72hrs, and 80%,100%,80% in the case of injecting 5cc meconium stained. The incidence of aspiration pneumonia in the meconium nonstained group was 20T, injecting 3cc to 48hrs passed, and 80%, injecting 5cc meconium nonstained to 72hrs passed. 4. Aspiration pneumonia occurred to the 18rabbits` both lungs and 5rabbits occurred to the right lung and 3 rabbits occurred to the left lung.