감염이나 면역계에 이상이 없고, 임신의 합병증이 없으며 자연유산이나 태아사망의 기왕력이 없는 임신 초기 임산부 12명, 중기 18명과 말기 32명을 대상군으로 하고, 대조군으로는 건강한 가임여성으로서 호르몬제를 비롯한 면역계에 영향을 미칠 약제를 사용하지 않은 30명으로 하여 immunobead법을 이용하여 임신 중 B, T임파구 및 아형의 변화를 조사하여 다음과 같은 결론을 얻었다. 1. 총임파구의 구성비는 대조군에서 32.6 ± 8.2%였고, 대상군에서는 임신이 진행함에 따라서 감소하여 임신중기와 말기의 구성비는 20.8 ± 4.4%, 20.4 ± 5.5%로서 대조군과 임신초기에 비해 통계적으로 유의한 감소가 있었다(p

Many studies have been performed to evaluate of lymphocyte subsets in pregnancy as well as functional aspects of cell mediated immunity during pregnancy. However, studies of circulating B lymphocyte, T lymphocyte and subsets during pregnancy have yield conflicting results. The aubhors evaluated the B lymphocyte, T lymphocyte and subsets at various stage of pregnancy and nonpregnant controls. As a group, pregnant women had significantly (p < 0.05) lower total lymphocyte component ratio in second trimester (20.8 ± 4.4 %) and third trimester (20.4 ± 5.5 %) than did controls (32.6 ± 8.2 %) and first trimester pregnant women. The mean absolute number of lymphocyte in pregnancy is 190.4 ± 540.9/mm3. Component ratio of B lymphocyte in pregnant women is 9.7 ± 2.6 % and mean absolute number is 188.8 ± 66.6/mm3, which are not significantly different compared with control group. Component ratio of T lymphocyte is significantly (p < 0.05) higher in second trimester pregnant women (86.2 ± 1.6 %) and third trimester pregnant women (86.0 ± 2.8 %) than first trimester pregnant women (79.2 ± 5.6 %) and nonpregnant control group (79.7 ± 3.1 %). Component ratio of T4 cells is significantly (p < 0.05) higher is second trimester pregnant women (47.8 ± 5.4 %) and third trimester pregnant women (47.0 ± 6.1 %) than control group (41.7 + 3.6 %) and first trimester pregnant women (40.7 ± 8.3 %). Absolute number of T4 cells is significantly (p , 0.05) higher in pregnant women (768.8 ± 261.2/mm) than control group (587.2 ± 149.9/mm). Component ratio of T8 cells is lower in first trimester pregnant women (36.9 ± 5.7 %) than control group (38.4 ± 3.2 %), but which is not significantly different. Absolute number of T8 cells is significantly (p < 0.05) higher in first trimester pregnant women(736.5 + 212.8/mm) than control group (539.4 ± 133.9/mm). T4/T8 ratio in pregnant women (1.21 ± 0.34) is not statistically different compared with control with control group (1.09 ± 0.14). T/B lymphocyte component ratio is significantly (p < 0