1987년 9월부터 1988년 8월까지 본 병원 산부인과에서 기능장애성 자궁출혈 환자 113례의 임상 및 자궁내막생검에 대한 연구로 다음과 같은 결과를 얻었다. 1. 연령분포는 40대에서 50%, 30대에서 23%, 50대에서 17%였다. 2. 평균 임신횟수는 56회였고, 분만횟수는 23회였다. 3. 출혈양상은 과다월경과 월경간 출혈이 동반되는 경우가 35%, 월경간 출혈이 27%, 폐경후 출혈은 166%였다. 4. 자궁내막의 조직소견은 증식기 내막이 63.7%, 분비기 내막이 23.9%, 내막 증식증이 8.8% 순이었다. 5. 표준화한 월경주기 14일후 자궁내막생검을 시행한 66례중 배란성출혈을 의미하는 분비기 내막은 20례(33%)로서 주로 무배란성출혈이 많았다.

Dysfunctional uterine bleeding is defined as bleeding from the uterine endometrium unrelated to anatomic lesions of the uterus. According to definition, the diagnosis of dysfunctional uterine bleeding seems to be a diagnosis of exclusion. Dysfunctional uterine bleeding is the most frequent problem of all gynecologic disease and occurs more frequently during puberty and in the perimenopausal period and is less common during the reproductive period. Pathologically, the endometrium of DUB patients represents the proliferative pattern most commonly. We performed the clinical and pathologic studies of DUB patients in order to evaluate the abnormal uterine bleeding and brief review of literature was made. 113 cases of dysfunctional uterine bleeding obtained by endometrial biopsy. The results were follows: 1. Age distribution of uterine bleeding was mainly 5th decade. 2. Dysfunctional uterine bleeding patients were mainly multigravidas and showed 5 ~ 6 times of pregnancy and 2 ~ 3 times of pregnancy. 3. Among variable bleeding patterns, menorrhagia with intermenstrual bleeding was the most common pattern. 4. The histologic findings of endometrium were proliferative phase, secretory phase, hyperplasia irregular shedding, atrophic endometrium in order of frequency. 5. According to endometrial biopsy, the incidence of anovulatory DUB was 67 % (46 cases out of 66 cases) and ovulatory DUB was 33 % (20 cases out of 66 cases).