미세수술을 이용한 난관 문합술시 봉합사, 복강내첨가물, 수술 후 경과기간별로 난관조직의 유착정도, 봉합사의 흡수유무, 복수존재유무, 난관유통검사, 조직학적 소견을 관찰하여 다음과 같은 결과를 얻었다 1 난관정도의 유착정도는 vicryl군과 nylon군이 dexon군에 비하여 약간 적었으나 유의한 차이는 없었고(P=0 1504), macrodex군이 생리적 식염수군과 대조군보다 비교적 적었으나 유의한 차이는 없었다(P=0 8325) 2, 봉합사별 흡수유무는 수술 후 60일에서 vicryl군은 완전흡수, dexon군은 1마리(16 7%)에서 부분흡수, nylon군은 전혀 흡수되지 않았다(P=0 0002) 3 난관유통성 검사결과는 vicryl군과 nylon군이 dexon군에 비해서 약간 우수하였으나 유의한 차이는 없었고(P=0 6218) macrodex군이 생리적 식염수군과 대조군에 비하여 우수하였다(P=0 048) 4 복수는 수술 후 60일에 macrodex군의 50%(3/6)에서 존재하였으나 생리적 식염수군과 대조군에서는 없었다 수술 후 60일과 90일의 경과기간에 따른 차이는 없었다(P=0 2059) 5 조직구와 다핵거대세포의 침윤에 의한 조직 반응과 섬유화는 vicryl군과 macrodex군이 각각의 비교군보다 적었다 이상과 같은 결과로 봉합사로는 vicryl과 nylon을 사용하고 복강내 첨가물로는 6% dexon을 주입하였을 때 조직의 유착이 적고 난관의 유통성이 우수하며 조직반응 및 섬유화가 가장 적어 난관의 미세복원수술에 이들의 사용이 좋을 것으로 사료되었다

Tubal sterilization has been increased progressively in young reproductive women and it has made tubal reversal using microsurgery increase consistently Pregnancy success rate by tubal reanastomosis using microsurgery has been reported approximately two times higher than the previous operation methods Microsurgical tubal reanastomoses were performed on bilateral fallopian tubes of 18 female rabbits using different suture materials and adjuvants Adhesions, absorption of suture materials, tubal patency, and presence of ascites were compared and tissue responsiveness was evaluated by histologic examinations of the restored tubes, and the results were as follows: 1 There was no difference in the degree of adhesion of the restored tubal tissue when the groups were compared according to the suture materials(P=0 1504) and the adjuvants(P=0 8325) 2 Absorption of suture material was marked in the vicryl and the dexon groups compared to the nylon(P=0 0002) 3 There was no difference in tubal patency between the vicryl, dexon, and nylon groups(P=0 6218), but more cases with free flow were found in the macrodex group compared to the normal saline and the control(P=0 048) 4 Ascites were observed in 50%(3/6) in the macrodex group on the 60th day after reanastomosis, whereas none was found in the normal saline and the control(P=0 0735) No difference was noted in the frequency of ascites between the 60 days and 90 days groups(P=0 2059) 5 Tissue responsiveness assessed by infiltrations of histiocytes and multinucleated giant cells, and fibrosis in histologic examination was less marked in the vicryl and the macrodex groups compared to corresponding group