임신말기 즉, 38∼42주의 만삭 임신(평균 체중 : 3323∼3520gm) 및 진통 특히 여러 가지 형태의 진통시에 양수내 prostaglandin(PG)F2α 및 PGE의 농도를 임부 80예에 대하여 각각 방사면역 측정법으로 측정하여 다음과 같은 결론을 얻었다 1 임신 말기에 진통 시작 전 양수내 PGF2α농도는 평균 1 09±0 27ng/ml였다 PGF2α농도는 38∼40주에서는 증가하고, 41∼42주에서는 감소하는 경향이 있었으나 유의한 차이는 없었다 PGE의 평균 농도도 유의한 차이는 없었으나 41주부터는 감소하는 경향이 있었다 2 자궁수축 자극검사후의 양수내 PGF2α 및 PGE의 평균 농도는 각각 0 89±0 44ng/ml, 0 60±0 25ng/ml로서 자궁수축 자극검사를 하지 않은 대조군과 유사하였다 3 자연진통군에서 자궁 경관이 3∼4㎝ 개대시 양수내 PGF2α의 평균 농도는 7 52±2 8ng/ml, PGE의 평균 농도는 3 26±1 75ng/ml로서 oxytocin 유도군의 PGF2α(2 74±1 01ng/ml) 및 PGE (0 59±0 19ng/ml) 농도에 비하여 유사한 차이는 없으나 높은 경향을 보였다 4 자연진통에 따른 자궁 경관이 점진적으로 확대되는 정도에 따라서 양수내 PGF2α농도는 현저하게 증가하였으며, 3∼4㎝ 개대시 7 52±2 8ng/ml, 9∼10㎝ 개대시 26 18±1 99ng/ml로서 양수내 PGF2α농도는 현저하게 증가하였다 따라서 경관 개대 정도와 양수내 PGF2α 농도와는 상관관계가 있었다 진통시 자궁 경관이 5∼6㎝ 개대시 양수내 PGE의 농도는 4 65ng/ml였으며, 경관 개대 정도에 따라 상관관계를 볼 수 없었다

In this study prostaglandin F2α and PGE concentrations in amniotic fluid during the late pregnancy of 38-42 weeks and different types of labor such as contraction stress test, and induced or spontaneous labor have been measured by radioimmunoassay Eighty subjects of normal term gravidas were studied and the results obtained were as follows 1 The mean concentration of PGF2α in amniotic fluid at term was 1 09±0 27ng/ml, being relatively constant Although there was a tendency of a progressive rise in PGF2αduring 38-40 weeks with gestation advanced and of a fall thereafter, no significant differences were found between two groups Profiles of PGE concentration with gestation advanced were similar to those of PGF2α 2 No differences were found in PGF2α and PGE concentrations in amniotic fluid between the short stimulation or contraction stress test and control groups 3 Both PGF2α and PGE levels in anmiotic fluid at early part of labor (cervical dilatation 4cm or 3) during onset of spontaneous labor seemed to be higher than those during the oxytocin induced labor, although differences were not statistically significant 4 Concentration of PGF2α in amniotic fluid at 1st stage of labor was significantly raised with advancing degree of cervical dilatation, while there was no change in PGE levels It is therefore concluded that PGF2α, compared with PGE, plays a major role in view of parturient aspect and once labor is initiated, PGF2α increment in amniotic fluid facilitates ripening of uterine cervix and uterine contraction