자궁경관점액의 Canalization

The importance of cervical mucus as an ovulation marker and its role in the survival and penetration of spermatozoa are today recognized everywhere. Human cervical mucus forms channels when dried under a cover-slip. The aim of the present investigation was to study the phenomenon of cervical mucus canalization in spontaneous ovulatory cycles and during treatment with gonadotropins for the induction of ovulation: to evaluate the correlation between this phenomenon of canalization and other parameters for the prediction of the time of ovulation such as measurement of plasma estradiol concentration, ultrasonic examination for monitoring of follicular growth, the measurement of the pattern of ferning and spinnbarkeit: and to verify the value of the clinical use of the phenomenon of canalization. The results were sumarized as follows: 1. Canalization appeared on the eighth day of the menstrual cycle and the number of the channels increased until the time of ovulation 2. The mean number of channels increased from 6 11 in AIH group, 18 11 in AID group, 26 16 in HMG group(Day -5) to a maximum of 24 9 in AIH group, 54 15 in AID group, 52 21 in HMG group(Day -1) and decreased to 14 10 in AIH group, 16 8 in AID group, 21 19 in HMG group(Day 0). 3. The maximum plasma estradiol(E2) concentration was 537 428 pg/ml in AIH group, 804 250 pg/ml in AID group, 1,234 521 pg/ml in HMG group(Day -2) and there was a good statistical correlation between the number of channels and plasma E2 concentration. 4. The maximum follicular diameter was 19.7 4.7mm in AIH group, 19.2 5.4mm in AID group, 16.6 3.8mm(Day -1) and after then decreased. There was a good statistical correlation between the number of channels and the follicular diameter. 5. The maximum grade of ferning was 2.1 1.1 in AIH group, 2.9 0.3 in AID group(Day -1) and 2.8 0.6 in HMG group(Day -2). The number of channels increased in proportion to the increase of the grade of ferning. 6. The maximum score of spinnbarkeit was 2.6 0.7 in AIH group(Day -1), 3.0 0 in AID group, and 2