Human Menopausal Gonadotropin , 배란유도 , 임신률

Ovulation induction with Human Menopausal Gonadotropin and Human Chorionic Gonadotropin is a form of hormone replacement therapy. HMG is a purified gonadotropin preparation extracted from the urine of postmenopausal women. Each ampule contains 75 IU of follicle stimulating hormone and 75 IU of luteinizing hormone. This study is a clinical trial to induce ovulation with HMG-HCG. For induction of ovulation, HMG-HCG was used clinically to the infertile women, who visited the Infertility Clinic in the Department of Obstetrics and Gynecology, S.N.U.H. from Feb. 1982 to Feb. 1985. The results were as follows: 1.HMG-HCG was given to 32 anovulatory women who were failed in ovulation with clomiphene citrate, one women with poor cervical mucus and one women with habitual abortions, in 111 treatment cycles. 2. The combinations of both clomiphene citrate and HMG-HCG were tried in 9 cycles(8.1%). 3. The mean ampules of HMG used in treatment were 28.5 ampules, of pregnancy, 21.9 ampules, and of ovarian hyperstimulation, 20.5 ampules, respectively. 4. The ovulation rate was 77.5%. 5. The pregnancy rate was 38.2%. 6. There was a significant improvement of pregnancy rate using USG and E2 rapid assay as monitoring methods. 7. The abortion rate was 33.3%. 8. The multiple pregnancy rate was 20.0%. 9. There was one congenital anomalous baby(e.g. transposition of great arteries) out of 9 newborns. 10. The rate of ovarian hyperstimulation, including mild and severe forms, was 16.2%.