1982년 6월부터 1983년 2월까지 9개월간 라미나리아 삽입법, PGE2의 경구투여법, PGF2a의 양막내주입법 및 옥시토신 정맥내점적법을 병용하여 중기임신중절을 시행한 30례에 대한 효과와 안전성을 조사 분석하고 과거 본 교실에서 조사 보고한 바 있는 15(S)-15methyl PGF2a의 양막내주입법 및 보조방법으로서 고장성요소 용액의 양막내주입법과 라미나리아삽입법을 병용하여 중기임신중절술을 시행한 108례에 대한 조사성적을 대조군으로 비교하여 다음과 같은 결과를 얻었다. 1. 연령은 31-35세군이 가장 많았고(40.0%) 임신주수는 21-22주가 제일 많았으며(33.3%) 분만회수가 초임부가 8례 경산부가 22례로 대부분 2-4회의 분만력을 가지고 있었다. 2. 적응증은 정신사회적문제가 대부분이었고(60.0%) 그 외 염색체이상, 풍진감염, 간질, 자궁내태아사망, 방사선의 노출등이었다. 3. 24시간내 유산성공율은 80.0%이었고 48시간내 유산성공율은 초임부가 100%, 경산부에서 90.9%로 전체 평균 93.4%였으며 이중 완전유산율은 76.7%이었다. 4. 평균 유산요소시간은 12.4시간이었으며 초임부가 15.4시간, 경산부가 11.2시간으로 분만회수가 많을수록 유산소요시간은 단축되는 양상을 나타내었으나 임신주수와는 특이한 관계가 없었다. 5. 실패한 2례중 1레는 양수의 파수로 진통이 소실되어 소파술이 시행되었고 다른 1례는 48시간이 되어도 반응이 없어서 THAM과 urea를 다시 양막내주입하여 유산시켰다. 6. THAM을 사용한 대조군과의 성적비교에서 유산성공율은 대조군의 95.4%와 유사한 결과를 나타내었으나 평균 유산소요시간은 대조군(15.4시간)보다 조사군(12.4시간)에서 다소 단축되었다. 7. 부작용 및 합병증은 8례(26.6%)였었는데 이중 4례(13.3%)에서 오심, 구토, 설사등 경증의 소화계장애가 있었고 그외 발열 2례, 다량 출혈과 경관열상이 각각 1례 있었다. 이는 대조군에서의 43.5%보다 현저히 감소하였다.

The efficacy and safety of administering prostaglandin F2a intraamniotically with a combination of laminaria and oral administration of prostaglandin E2 followed by constant intravenous infusion of oxytocin for induction of midtrimester abortion was studies in 30 patients, and compared control groups with were those of administering 15(s)-15 methyl prostaglandin F2a intraamniotically with laminaria and hypertonic solution of urea as a adjunct for midtrimester abortion which had been studies previously on the Dept. of Obstet. & Gynecol. Kung Hee University at 1980. 1. The studies were preformed in most cases between 21-24 weeks gestational age, and age range was 31-35 years old were most common. In this study group, 8 cases were primigravida and 22 cases were multigravida, most of them have 2-4 times of delivery history. 2. The indications, were psycho-social problems, chromosomal anomalies, rubella infection, epilepsy, FDIU, irradiation, and psychosocial problems were most common cause. 3. Abortion was successfully induced in 80% within 24 hours and in 93.4% within 48 hours. In primigravida termination of pregnancy within 48 hours was successful in 100% of cases, and multigravida was 90.9%. Complete abortion rate of this group was 76.7%. 4. Midtrimester abortion was successfully induced in 28 of 30 patietns and the mean abortion time was 12.4 hours. Multigravida aborted somewhat faster than nulligravida, but the difference was not significant, and abortion time was not relate to gestational weeks. 5. 2 cases were failed in this study group. In 1 cases of them, labor pain disappeared due to rupture of membrane, so dilatation and evacuation was performed. And in the other case, labor pain was not developed after 48 hours, so THAM and urea was inserted intraamniotically. 6. In comparision with control groups, study group (93.4%) was the nearly same abortion rate as control groups (mean 95.4%) and the abortion time was somewhat shorter in study group(12.4 hours) than in control groups(mean 15.4 hours). 7. Side effects was reduced more in study groups (26.6%) than in control groups (mean 43.5% ) and the most common side effect was a gastrointestinal symptoms(13.3%) such as nausea, vomiting and diarrhea. Others included transient pyrexia, excessive hemorrage and mild degree of cervical laceration. These side effects was not serious and in general well tolerated by patietns with appropriate conservative treatments and never required termination. Therefore, the method was proved a safe and effective means of terminating pregnancies in second trimester.