A simple, effective, non-surgical female sterilization procedure that can be applied on an outpatient basis would be of potential benefit in family-planning programs. We have undertaken a clinical trial of MCA in 30 cases of ambullatory women who wished to be sterilized. MCA is a tissue adhesive which can be delivered transcervically to the fallopian tubes by means of the FEMCEPT-MCA device. In our trial of ambullatory patients treated with the FEMCEPT-MCA system, 1. the bilateral tubal closure rate was 80%(24 bilateral tubal closure among 30 women) in the first application. 2. there have been no significant complications or side effects. 3. there were 2 cases of pregnancies among 24 women who had proven bilateral tubal closure one was intrauterine pregnancy after 13 months and the other was ectopic pregnancy after 17 months. The FEMCEPT-MCA system requires minimal technical skills for its application and appears to be readily adaptable to mass production and distribution. It holds promise as a new method for permanent female contraception. Its wide spread use will depend upon achieving a high closure rate in a large series of patients.