1981년 9월 1일부터 1982년 2월 28일까지 6개월간 한양대학교 의과대학 부속병원 산과에서 조산 억제 목적으로 magnesium sulfate를 정주 투여받은 조산통 환자 26명과 유도 분만을 위해 입원한 정상 만삭 임신 임부 18명, 산전 관리를 위해 외래를 방문한 정상 중 기 임신 임부 23명을 대상으로 혈중 Mg 및 Ca 농도를 측정, 비교 관찰한 결과 다음과 같은 결론을 얻었다. 1. 유도 분만을 위해 자궁 수축제를 투여한 정상 만삭 임신 임부에서 진통전후의 혈중 Mg 및 Ca 농도의 변화는 없었다. 2. 정상 증기 임신 임부와 정상 만삭 임신 임부의 임신 주령에 따른 혈중 Mg 및 Ca 농도의 차이는 없었다. 3. Magnesium sulfate를 정주 투여받은 조산통환자에서 조산 억제가 성공한 예와 실패한 예간의 혈중 Mg 및 Ca 농도의 차이는 없었다. 이로서 혈중 Mg 및 Ca 농도의 측정에 의한 조산 억제 성패의 예측은 불가능한 것으로 생각된다.

This clinical study was performed to evaluate the predictability of the prognosis of premature labor by measuring the concentrations of Mg and Ca in patients who were under the control of magnesium sulfate. The study group comprised 26 patients with preterm labor who had been controlled with magnesium sulfate, and was compared with control group I, 23 patients of normal full term who had been admitted for induction of labor and control group II. 18 patients of normal midtrimester who had visited to our outpatient clinic for antenatal care during the period from Sep. 1, 1981 to Feb. 28, 1982 at the Department of Obstetrics and Gynecology of Hanyang University Hospital. From all the patients, the level of serum Mg and Ca were measured and analysed. Results are as follows: 1) In the control group I, the mean levels of serum Mg and Ca were 2.35±0.18 mg/dl and 8.99±0.39 mg/dl respectively before the labor. 2.32±0.19 mg/dl and 9.09±0.43 me/dl during the labor. There were no differences between the values before and during the labor. 2) In the control group II, the mean levels of serum Mg and Ca were 2.31±0.17 mg/dl and 9.08±0.55 mg/dl respectively. and there were no differences compared to those before the labor in the control group I. 3) In the study group, the mean levels of serum Mg and Ca before intravenous infusion of magnesium sulfate were 2.56±0.35 mg/dl and 8.91±0.74 mg/dl in the cases of success. and 2.61±0.24mg/dl and 8.88±0.65 mg/dl in those of failure. The mean levels after infusion of magnesium sulfate were 3.10±0.27 mg/d and 8.03±0.85 mg/dl in the cases of success, and 3.10±0.20mg/dl and 7.88±0.73mg/dl in those of failure respectively. There were no stastical differences between the values in the cases of success and failure in both occasions before and after infusion of magnesium sulfate. Thus, it was not helpful to predict the prognosis in the management of the premature labors with magnesium sulfate by measuring the serum concentrations of Mg and Ca.