유도 분만이 적용이 되는 산모 30예(초산부 15명, 경 산부 15명)를 대상으로 질용 PGE₂를 자궁경부와 질후 벽 사이에 있는 함요부에 삽입하여 다음과 같은 결과 를 얻었다. 1. 유도분만 성공율은 77%(23/30예)로 초산부 66% (10/15예), 경산부 87%(13/15예)이었다. 2. 질용 PGE₂정제 투여로부터 진통초발까지의 소 요시간은 초산부 4시간 12분, 경산부 5시간 17분으로 평균 4시간 45분이었고 투약개시부터 태아만출까지의 소요시간은 초산부 12시간 56분, 경산부 8시간 9분으 로 평균 10시간 33분이었다. 3. 유도분만 30예 중 질용 PG단독용법으로 분만유 도에 성공한 23예에서 78%(18/23예)가 정상질식분만 에 성공하였고 질식흡인분만은 22%(5/23예)이었으며, 질용 PG의 투여와 oxytocin 정맥점입을 병용한 7예 중 6에에서 결국 질식분만에 성공하였으므로 이것까지 포 함한 총 유도분만성공율은 96.6%(29/30예)이었다. 4. 질용 PGE₂1정(=3mg)투여로 유도분만에 성공 한 경우는 95%(20/21예)이었고 1정을 추가투여한 9예 중 3예가 유도분만에 성공하여 추가 투여한 경우의 성 공율은 33%이었다. 5. 분만된 신생아의 Apgar score는 1분과 5분에서 모두 7∼8이상으로 양호한 편이었고 태변염색된 경우 는 10%(3/30예)이었다. 6. 고위험군의 산모 9예에 Non Stress Test를 시행 하여 전부 reactive pattern을 관찰하였고 이중 4예에서 Contraction Stimulation Test를 추가 시행하여 모두 negative pattern으로 관찰된 바, 태아감시 도중 이상 소견은 없었다. 7. 투약 도중 질용 PGE₂에 의한 부작용을 타나내는 산모는 없었다. 이상의 결과로 질용 PGE₂는 간편하고 효과적이며 부 작용이 거의 없는 유보분만 제재로서, 5 이하의 낮은 score에도 불구하고 질용 PGE₂단독 사용으로 높은 성 공율을 보였다.

Induction of labor for obstetric or medical reasons in an integral part of modern obstetric practice. The standard method employed in the authors` institution has been amniotomy and intravenous oxytocin for many years while, during the last 2 or 3 years, oral administration of prostaglandin E₂ tablets has been used before intravenous infusion of oxytocin to induce labor as well as to ripen the cerⅵx. Also a new ideal method for the induction of labour would be simple, safe, effectⅳe and noninvasⅳe, thereby increasing acceptance by the patient and reducing the risks associated with amniotomy. The intravaginal administration of prostaglandin E₂ tablets which ⅰs the easiest way to apply prostaglandin can proⅵde these benefits. This is a report to determine efficiency of vaginal prostaglandin E₂ for the induction of labor. Induction of labor was performed in the cases of 30 women between 39th and 44 wks of pregnancy who were admitted to the Department of Obstetrics of Kyung Hee University Hospital from March to May 1983. The pelⅵc score for induction was determined by Bishop scoring method, and the Bishop score of the patient of our studies were all below 5. The results were as follows. 1. The success rate in induction with vaginal prostaglandin E₂ were 66% in primigraⅵda(10 of l5 cases) and 87%(13 of 15 cases) in multigraⅵda. 2. Mean induction delⅳery time was 12.93 hours in primigravida and 8.15 hours in multigraⅵda. Time interval from medication to actⅳe labour was 4.2 hours in primigraⅵda and 5.3 hours in muitigraⅵda. 3. In 23 cases of induction of labour with only vaginal prostaglandin E₂, normal vaginal delivery was 78%(18 of 23 cases) vacuum delivery was 22%(5 of 23 cases) and in 7 cases who were failed induction delivery by vaginal PGE₂ Only, 6 cases (86%) were vaginal delivery and 1 case(14%) was cesarean delivery. 4. The success rate in case of vaginal PGE₂ 3mgs was 95%(20 of 21 cases) and of vaginal PGE₂ 6mg was 33%(3 of 9 cases) 5. Fetal Apgar score was all over 7 or 8 at 1 and 5 minutes, and meconium stained fetus was 10%(3 of 30 cases) 6. ln 9 cases of fetal monitoring patients, NST was all reactive and 4 of 9 cases who were under CST, they were all negative. 7. ln failed cases with only vaginal PGE₂, successful induction rate with combined therapy of vaginal PGE₂ and oxytocin was 86%(29 of 30 cases), and cesarean delivery was only 1 case.